Impact of epigenetic mechanisms in re-emerging virusesArticle Published on 2023-03-012023-06-10 Journal: Travel medicine and infectious disease [Category] Fulltext, 원숭이두창, [키워드] COVID-19 Epigenetic immune responses molecular mechanisms mpox Oncology biomarkers Re-emerging viruses. [DOI] 10.1016/j.tmaid.2022.102535 PMC 바로가기
Epigenetic perspectives of COVID-19: Virus infection to disease progression and therapeutic controlResearch article Published on 2022-12-012022-10-05 Journal: Biochimica et biophysica acta. Molecular basis of [Category] COVID19(2023년), SARS, 변종, 신약개발, 유전자 메커니즘, 치료제, [키워드] ACE2 analysed antagonistic autophagy caused Cell cellular metabolism cellular processe Course COVID-19 death Disease progression enzyme Epigenetic epigenetics example expression profile function genes encoding Genome Host host cell IL-6 Infection investigated Laboratory Lipid mechanism membrane metabolic activity metabolic pathway methionine pathogen invasion patients Perspective progression rDNA Regulation replication mechanism ribosome S-adenosylmethionine SARS-CoV-2 sera social isolation the disease the patient therapeutic therapy tissue viral loads virus virus particle virus replication [DOI] 10.1016/j.bbadis.2022.166527 [Article Type] Research article
Interaction of HDAC2 with SARS-CoV-2 NSP5 and IRF3 Is Not Required for NSP5-Mediated Inhibition of Type I Interferon Signaling PathwayArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 치료제, [키워드] abrogate activated addition bind binding biological significance cellular processe complex disrupt DNA Epigenetic Evidence expression favor Gene Expression HDAC2 Host host antiviral response IFN response IFN signaling pathway IFN-stimulated genes IFNβ IL-1β IL-6 immune response gene inhibit inhibition inhibitory interact Interaction interferons involved IRF3 nsp5 over Pathogenesis pathway promote promoter promoters protease Protease activity protein interaction protein-protein interactions reduce Regulation Replication repress required RNA SARS-CoV-2 SARS-CoV-2 protein Signaling signaling pathway significantly subset Type Type I IFN type I IFN signaling. type I interferon viral infection viral infections Viral protein virus [DOI] 10.1128/spectrum.02322-22 PMC 바로가기
A machine learning approach utilizing DNA methylation as an accurate classifier of COVID-19 disease severityArticle Published on 2022-10-192022-11-16 Journal: Scientific Reports [Category] 변종, [키워드] applied approach average benefit Classifier Cohort COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 pandemic dataset DNA methylation Epigenetic external validation Gene Expression Omnibus identify increased risk individual logit Methylation methylation site NCBI non-infected outcome pathology platform Pneumonia processed produced provide random forest classification Receiver operator characteristic severe COVID-19 disease Therapies unique utility Vaccine variant [DOI] 10.1038/s41598-022-22201-4 PMC 바로가기
A Review: Highlighting the Links between Epigenetics, COVID-19 Infection, and Vitamin DArticle Published on 2022-10-142022-11-16 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Apoptosis changes in Chromatin structure contribute COVID-19 COVID-19 infections disease risk drug Effect Epigenetic epigenetic modification epigenetics Evidence Gene Expression Health help highlight Host immune response Immunity immunomodulatory effect indicate individual Infection Inflammation involved mechanisms Modification modulated multifunctional outcomes pathophysiology Prevent proliferation receptor receptor function reduced regulate SARS-CoV-2 target therapeutic therapeutic drug Treatment Vaccine viral outbreak virus Vitamin D vitamin D. while [DOI] 10.3390/ijms232012292 PMC 바로가기
Evidence for the heterologous benefits of prior BCG vaccination on COVISHIELD™ vaccine-induced immune responses in SARS-CoV-2 seronegative young Indian adultsArticle Published on 2022-10-042022-11-16 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] Activation Adaptive immune response antibodies antibody BCG BCG vaccination benefit booster breadth CD4+ CD8+ T-cell changes changes in chromatin Combination COVID-19 vaccines Delta Effect effector memory eight elevated ENhance Epigenetic Evidence expressing greater Heterologous highlighting IL-1β IL-2 immune response Immunity in-depth analysis India marker memory T-cell response mutant NAb Neutralizing provide revaccination SARS-CoV-2 seronegative significantly higher subset T cell T-cell Response tested TNF-α TNF-α expression trained immunity. Tuberculosis vaccination Vaccine vaccine-induced immune response [DOI] 10.3389/fimmu.2022.985938 PMC 바로가기
Comparing the expression levels of tripartite motif containing 28 in mild and severe COVID-19 infectionArticle Published on 2022-10-032022-11-15 Journal: Virology Journal [Category] 치료제, [키워드] 25-hydroxyvitamin D age Analysis antiviral immune response association cholesterol control group coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 patients determine differential expression disease downregulation enrolled Epigenetic erythrocyte sedimentation rate ESR evaluated expression level HDL healthy control high-density in both group indicated Infection LDL low-density Mild mild infection motif mRNA level multivariate logistic regression Patient patients PCR cycle polymerase chain Proteins qPCR reduction in required Severe COVID-19 Infection severe group Severe infection severe infections severity severity of COVID-19 significantly lower the mean threshold TRIM28 Tripartite Motif Tripartite motif containing 28. was used [DOI] 10.1186/s12985-022-01885-0 PMC 바로가기
Expression analysis of miRNA hsa-let7b-5p in naso-oropharyngeal swabs of COVID-19 patients supports its role in regulating ACE2 and DPP4 receptorsArticle Published on 2022-10-012022-11-15 Journal: Journal of Cellular and Molecular Medicine [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, [키워드] ACE2 Analysis control sample coronavirus disease COVID-19 COVID-19 patient COVID-19 patients differential expression downregulation DPP4 enzyme Epigenetic functional Genes hsa-let7b-5p investigated involved low expression mechanism miRNA miRNAs miRNAs. modulation naso-oropharyngeal swab Novel coronavirus NPs overexpressed overexpression progression receptor Regulation reported respiratory responsible SARS-CoV-2 SARS-COV-2 infection significantly statistically significant Support the disease therapeutic target transcripts [DOI] 10.1111/jcmm.17492 PMC 바로가기
Epigenetic mechanisms and host factors impact ACE2 gene expression: Implications in COVID-19 susceptibilityResearch article Published on 2022-10-012022-10-05 Journal: Infection, genetics and evolution : journal of mol [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 gene ACE2 protein age angiotensin-converting enzyme 2 Arterial hypertension association Asthma BMI body mass index changes in clinical variable clinical variables COVID-19 COVID-19 susceptibility described determinant disease susceptibility DNA methylation Epigenetic epigenetics evaluate evaluated expression expression profile Factor Host host cell host factors Infection involved Male sex mechanism Methylation molecular cause mRNA expression nasopharyngeal swab sample obesity overexpression Peripheral blood promoter region quantified regulated Result risk factor RT-qPCR SARS-CoV-2 SARS-COV-2 infection Sex significant difference smoking study group susceptibility the disease type II diabete underlying disease Variability variable virus volunteers was determined [DOI] 10.1016/j.meegid.2022.105357 [Article Type] Research article
SARS-CoV-2 disrupts host epigenetic regulation via histone mimicryArticle Published on 2022-10-012022-11-16 Journal: Nature [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome Affect antiviral response attenuate caused chromatin Control coronavirus coronavirus disease COVID-19 Critical Deletion demonstrated disrupt Epigenetic function global pandemic Host host cell host cell response Infection mechanism mimicking molecular basis motif ORF8 ORF8 gene post-translational modification promote Protein provide recent Region Regulation required SARS-CoV-2 severity of COVID-19 suppress the SARS-CoV-2 transcriptional regulation transcriptional response viral genome Viral protein [DOI] 10.1038/s41586-022-05282-z PMC 바로가기